The article has been automatically translated into English by Google Translate from Russian and has not been edited.

Scientists have made new conclusions about how coronavirus penetrates the body

'17.06.2020'

Source: Foreign press

“It is not only the viruses of the common cold that the nasal mucosa loves. Sars-Coronavirus-2 also prefers to use it to enter the body and spread in it, American scientists from North Carolina found out. Their findings have been published in the scientific journal Cell, ”the German edition of Frankfurter Rundschau reports, citing "Inopressa".

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“Initially, many scientists assumed that the coronavirus first infects the tissue of the pharynx and then, during the course of the disease, enters the lower respiratory tract. It seemed that the fact that at first a runny nose was considered rather a rare symptom in Covid-19, and in general after infection, the first symptom was often sore throat. "

But now scientists have come to the conclusion that the virus is following a different path. “In their opinion, it first affects the cells of the nasal cavity and from there with physiological fluids it enters the deep parts of the lungs. Sars-CoV-2 can also enter the brain through the nose, which, according to the available data, can also be infected by the virus. "

“To study the path of the virus, the researchers reconstructed in the laboratory, based on the available genetic data on Sars-CoV-2, an artificial twin that glows green when fluorescent. Using a highly sensitive method, they also studied different types of cells in the mucous membranes of the nose, pharynx and bronchi to determine their ACE2 receptor content. This receptor is critical in Covid-19 because the virus clings to it to get inside the cell. Scientists found that the concentration of ACE2 receptors decreased in the direction from the upper respiratory tract to the lower. This means that there were more of them in the cells of the nasal mucosa than in the cells of the pharynx and bronchi ”.

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In the second part of the study, the scientists found that “antibodies found in the blood of patients after SARS disease, in a laboratory experiment, could to a small extent inhibit the multiplication of Sars-CoV-2. This may indicate that people who have had SARS or MERS have partial immunity against Sars-CoV-2, which contributes to an easier course of the disease. Scientists also believe it is possible that people who have had one of the common colds caused by coronaviruses may have such partial immunity. ”

“However, these results do not allow us to conclude that another route - direct infection of the lungs - does not occur. However, it now seems “less likely”. (…) Assuming that the virus first infects the nasal mucosa or only then the lungs, this time can be used to prevent the development of a lung infection through therapy, ”reports Frankfurter Rundschau.

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